I have a couple of projects on the go at the moment, although not at the same time in Reaper that is, and this problem is occurring with both. (I've v2.55 installed, Windows XP a M-Audio Delta 1010LT, 2GB Ram) Basically, I'm working on the midi parts on both projects and I can be auditioning VST sounds or recording a vst when Reaper just disappears. No warning, no error codes nothing it just vanishes. When I restart Reaper I sometimes get the message that my Delta 1010 Asio driver couldn't be enabled and that my Delta inputs/ outputs couldn't be found. Like I say, this message doesn't always happen as sometimes I can restart Reaper as normal. The upshot is that I lose whatever work hasn't been saved, mainly due to not having the chance to do so. It seems to happen in conjunction with VST's. Any ideas what's going on? Its doing my head in - you can be really into the project and flowing along, then suddenly that all stops, the fire doused, so to speak. I've never had the problem working with mic's or guitars etc by the way.